Congenital insensitivity to pain with anhidrosis (CIPA): sebuah artikel dan manajemen anestesi

Ina Karina Putri G. Sugihen

Abstract


Congenital insensitivity to pain with anhidrosis (CIPA) is hereditary sensory and autonomic neuropathies (HSAN) type IV caused by mutations in NTRK1 gene (neurotrophic tyrosine kinase receptor 1) located in chromosome 1q21-22, encoding the tyrosinase domain receptor high affinity nerve growth factor. It is characterized by anhidrosis, insensitivity to painful stimuli and mental retardation. Given their low prevalence from few reported cases, it is important to know its sign and symptomp to be considered in the differential diagnosis. Therapy for CIPA remains unclear. Complication prevention is the only possible treatment of CIPA. In anesthetic management during surgery, those patients should still administred by analgesics for sedation and anxiolytic effects.


Keywords


anhydrosis; anesthetic; CIPA; pain

Full Text:

PDF

References


Akdogan A, Eroglu A, Kutanis D, Cekic B. (2016). Anesthetic management in a patient with congenital insensitivity to pain syndrome for lower extremity surgery. Int J Anesth Res, 4(10),340-2.

Bakri FG, Wahbeh A, Sneina AA, Khader AA, Obeidat F, Alawwa I. (2016). Congenital insensitivity to pain and anhydrosis due to a rare mutation and that is complicated by inflammatory bowel disease and amyloidosis: a case report. Clinical Case Report, 4(10),997-1000.

Daneshjou K, Jafarieh H, Raaeskarami SR.(2012). Congenital insensitivity to pain and anhydrosis (CIPA) syndrome; a report of 4 cases. Iranian Journal of Pediatrics, 22(3), 412–2.

Dearborn G.(1932). A case of congenital general pure analgesia. Journal of Nervous & Mental Disease, 75(6):612–5.

Kim JS, Woo YJ, Kim GM, Kim CJ, Ma JS, Hwang TJ. (1999). Congenital insensitivity to pain with anhidrosis: a case report. J Korean Med Sel, 14, 460.

Nagasako EM, Oaklander AL, Dworkin RH. (2003). Congenital insensitivity to pain: an update. Pain, 101(3), 213-9.

Nabyev VN, Seneran H, Aksoy MC. (2018). Congenital insensitivity to pain syndrome with anhidrosis. Review of literature. J Pediatrics & Pediatr Med, 2(4), 14-20.

Oliveira CR, Paris VC, Pereira RA, Lara FS. (2009) Anesthesia in a patient with congenital insensitivity to pain and anhidrosis. Rev Bras Anestesiol, 59(5), 602-609.

Parrott LM. (2013)Anesthetic Management of a Patient With Congenital Insensitivity to Pain: A case report. AANA Journal, 81(5), 376- 8.

Pérez-López LM, Cabrera-González M, Iglesia DG, Ricart S, Knörr-Giménez G. (2015). Update review and clinical presentation in congenital insensitivity to pain and anhidrosis. Case Reports in Pediatrics,:1-7.




DOI: https://doi.org/10.52364/sehati.v2i1.14

Refbacks

  • There are currently no refbacks.


Copyright (c) 2022 Pelantar Press

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.